IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta
 
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Sequence Viewer
Gene
IKBKB
Synonyms
IKKB
Protein Name
Inhibitor of nuclear factor kappa-B kinase subunit beta
UniProt ID
O14920 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000404920
NCBI Gene ID
3551
Molecular Weight
86564
Protein Length
756
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 4kik)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
2.7.11.10; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
[I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+)
Localization
Cytoplasm,Nucleus,Membrane raft;
Function
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Gene Ontology
GO:0035631; GO:0009898; GO:0005829; GO:0008385; GO:0045121; GO:0005634; GO:0005524; GO:0042802; GO:0008384; GO:0046982; GO:0042803; GO:0004672; GO:0019901; GO:0004674; GO:0097110; GO:0002479; GO:0071356; GO:0030866; GO:0038095; GO:0007249; GO:0006954; GO:0045087; GO:0070498; GO:0002756; GO:0043066; GO:1903347; GO:0035509; GO:0018105; GO:0043123; GO:0051092; GO:0045944; GO:0045893; GO:0072659; GO:0006468; GO:1903140; GO:0042325; GO:0010803; GO:0009615; GO:0002223; GO:0051403; GO:0050852; GO:0035666; GO:0033209; GO:0016032
 
Gene Ontology