PPP1R12A | Protein phosphatase 1 regulatory subunit 12A
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PPP1R12A
Synonyms
MBS MYPT1
Protein Name
Protein phosphatase 1 regulatory subunit 12A
UniProt ID
O14974 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000261207
NCBI Gene ID
4659
Molecular Weight
115281
Protein Length
1030
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2kjy)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Cytoplasm,Cytoskeleton,Stress fiber;
Function
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
Gene Ontology
GO:0031672; GO:0015629; GO:0005813; GO:0043292; GO:0005737; GO:0005829; GO:0005925; GO:0000776; GO:0005654; GO:0072357; GO:0030018; GO:0071889; GO:0004857; GO:0019208; GO:0019901; GO:0035690; GO:0007098; GO:0000278; GO:0043086; GO:0035508; GO:0045944; GO:0006470; GO:0030155; GO:0035507; GO:0046822; GO:0007165
 
Gene Ontology