CaMKinet | Result

Gene

SMAD7

Synonyms

MADH7 MADH8

Protein Name

Mothers against decapentaplegic homolog 7

UniProt ID

O15105 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000262158

NCBI Gene ID

4092

Molecular Weight

46426

Protein Length

426

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2djy)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Cytoplasm;

Function

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Gene Ontology

GO:0005813; GO:0005737; GO:0005829; GO:0001650; GO:0005654; GO:0005634; GO:0005886; GO:0032991; GO:0005667; GO:0048185; GO:0008013; GO:0005518; GO:0000981; GO:0070411; GO:0046872; GO:0044212; GO:0030617; GO:0034713; GO:0031625; GO:0034333; GO:0048844; GO:0030509; GO:0034629; GO:1990830; GO:0071560; GO:0030514; GO:0030336; GO:0043433; GO:0010719; GO:0060394; GO:0033137; GO:0010801; GO:0031397; GO:0002725; GO:2000320; GO:2000317; GO:0010944; GO:0000122; GO:0030512; GO:0051444; GO:0060389; GO:0022409; GO:0032436; GO:0031398; GO:0045944; GO:0016579; GO:0050821; GO:0032925; GO:0055117; GO:0010717; GO:0017015; GO:0060373; GO:0034616; GO:0007179; GO:0001657; GO:0055010; GO:0060412