CaMKinet | Result

Gene

TP73

Synonyms

P73

Protein Name

Tumor protein p73

UniProt ID

O15350 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000340740

NCBI Gene ID

7161

Molecular Weight

69623

Protein Length

636

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1cok)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Cytoplasm;

Function

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

Gene Ontology

GO:0030054; GO:0000785; GO:0005829; GO:0005794; GO:0043231; GO:0005739; GO:0005654; GO:0005634; GO:0001228; GO:0003700; GO:0000981; GO:0042802; GO:0097371; GO:0046872; GO:0002039; GO:0019901; GO:0000978; GO:0008134; GO:0044212; GO:0000187; GO:0007050; GO:0006974; GO:0008630; GO:0042771; GO:0001822; GO:0006298; GO:0060044; GO:0008285; GO:0045665; GO:0071158; GO:0048714; GO:1900740; GO:0045944; GO:0045893; GO:0051262; GO:0042981; GO:0010468; GO:1902036; GO:0007346; GO:1901796; GO:0042493; GO:0010243; GO:0016032