Protein Name
Actin-related protein 2/3 complex subunit 5
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
16320
Protein Length
151
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytoskeleton,Cell projection,Nucleus;
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Gene Ontology
GO:0015629; GO:0005885; GO:0005737; GO:0005829; GO:0005768; GO:0070062; GO:0005576; GO:1904813; GO:0005925; GO:0030426; GO:0030027; GO:0005634; GO:0034774; GO:0035861; GO:0051015; GO:0005200; GO:0030036; GO:0051639; GO:0034314; GO:0016477; GO:0048013; GO:0038096; GO:0097581; GO:0030011; GO:0061024; GO:0061842; GO:0043312; GO:0021769; GO:0014909