Protein Name
Transient receptor potential cation channel subfamily V member 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
94948
Protein Length
838
Protein Domain
3D Structure
(PDB ID : 2nyj)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell junction,Synapse,Postsynaptic cell membrane,Cell projection,Dendritic spine membrane,Cell membrane;
Function
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.Isoform 3: Does not display channel activity in response to noxious chemical compounds, such as capsaicin and the vanilloid resiniferatoxin. Channel activity is not elicited by mildly acidic extracellular pH, and only slight channel activity is observed in response to noxiuos heat stimuli.
Gene Ontology
GO:0030054; GO:0005829; GO:0030425; GO:0032591; GO:0009897; GO:0016021; GO:0005887; GO:0031226; GO:0016020; GO:0005739; GO:0043025; GO:0005886; GO:0045211; GO:0045202; GO:0005524; GO:0005262; GO:0015278; GO:0005516; GO:0005261; GO:0008324; GO:0017081; GO:0005231; GO:0005230; GO:0042802; GO:0005216; GO:0015276; GO:0046872; GO:0035091; GO:0051219; GO:0097603; GO:0004888; GO:0048266; GO:0098703; GO:0070588; GO:0006816; GO:0071468; GO:0071312; GO:0071318; GO:0071345; GO:0071363; GO:0034605; GO:1990090; GO:0071502; GO:0071356; GO:0050968; GO:0050965; GO:0050960; GO:0002024; GO:0001660; GO:0014047; GO:0006954; GO:0006629; GO:0001774; GO:0090212; GO:0010459; GO:0010917; GO:0003085; GO:0000122; GO:0002790; GO:0043065; GO:0007204; GO:0060454; GO:0045429; GO:0051289; GO:1901594; GO:0009408; GO:0043434; GO:0009268; GO:0050954; GO:0060083