Protein Name
Protein Mdm4
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
54963
Protein Length
489
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Function
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
Gene Ontology
GO:0005634; GO:0019899; GO:0046872; GO:0003283; GO:0003181; GO:0008283; GO:0030330; GO:0003203; GO:0045023; GO:0003170; GO:0043066; GO:0071157; GO:0042177; GO:0000122; GO:0008284; GO:0065003; GO:0002027; GO:0003281