STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cytoplasm,Cytosol,Nucleus,Mitochondrion matrix,Mitochondrion outer membrane;

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).

GO:0005737; GO:0005829; GO:0005759; GO:0005741; GO:0005654; GO:0005634; GO:0032991; GO:0008013; GO:0031490; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0034246; GO:0019901; GO:0000978; GO:0043565; GO:0001221; GO:0008134; GO:0007568; GO:0001547; GO:0048854; GO:1904646; GO:0071386; GO:0071333; GO:0071456; GO:1990090; GO:0034599; GO:0019221; GO:0030330; GO:0097192; GO:0042593; GO:0001544; GO:0008286; GO:0006390; GO:0090090; GO:0030336; GO:0045665; GO:0000122; GO:0097150; GO:0001556; GO:0001542; GO:0043065; GO:2000353; GO:0045648; GO:1901300; GO:0043525; GO:1903428; GO:0045944; GO:0045893; GO:2000177; GO:0006357; GO:0006417; GO:0071548; GO:0031667; GO:1990785; GO:0033209