KCNQ2 | Potassium voltage-gated channel subfamily KQT member 2
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer
Gene
KCNQ2
Synonyms
-
Protein Name
Potassium voltage-gated channel subfamily KQT member 2
UniProt ID
O43526-4 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000345523
NCBI Gene ID
3785
Molecular Weight
95848
Protein Length
872
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 5j03)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane;
Function
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).
Gene Ontology
GO:0043194; GO:0016021; GO:0005887; GO:0033268; GO:0005886; GO:0008076; GO:0030506; GO:0005516; GO:0005251; GO:0005249; GO:0007268; GO:0007399; GO:0071805; GO:0034765
 
Gene Ontology