CaMKinet | Result

Gene

SMAD6

Synonyms

MADH6

Protein Name

Mothers against decapentaplegic homolog 6

UniProt ID

O43541 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000288840

NCBI Gene ID

4091

Molecular Weight

53497

Protein Length

496

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Gene Ontology

GO:0005737; GO:0005829; GO:0005794; GO:0016604; GO:0005634; GO:0032991; GO:0005667; GO:0003682; GO:0070410; GO:0000981; GO:0070411; GO:0042802; GO:0046872; GO:0070412; GO:0000978; GO:0044212; GO:0030617; GO:0070698; GO:0034713; GO:0031625; GO:0035904; GO:0003180; GO:0030509; GO:0031589; GO:0060976; GO:0045444; GO:0006955; GO:0003183; GO:0043066; GO:0030514; GO:0008285; GO:0030279; GO:0045668; GO:0060394; GO:0010991; GO:0030512; GO:0003148; GO:1902895; GO:0003184; GO:0043627; GO:0034616; GO:0007179; GO:0001657; GO:0003281; GO:0007352