Protein Name
Neuronal migration protein doublecortin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
40574
Protein Length
365
Protein Domain
3D Structure
(PDB ID : 1mjd)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cell projection;
Function
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Gene Ontology
GO:0005930; GO:0005856; GO:0005829; GO:0005874; GO:0005875; GO:0043005; GO:0008017; GO:0019901; GO:0035082; GO:0007417; GO:0035556; GO:0007399; GO:0001764; GO:0042461; GO:0060041