Arhgef7 | Rho guanine nucleotide exchange factor 7
 
Sequence Viewer
Gene
Arhgef7
Synonyms
Pak3bp Pixb
Protein Name
Rho guanine nucleotide exchange factor 7
UniProt ID
O55043 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSRNOP00000017947
NCBI Gene ID
114559
Molecular Weight
73140
Protein Length
646
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 2ak5)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell junction,Focal adhesion,Cell projection,Ruffle,Cytoplasm,Cell cortex,Cell projection,Lamellipodium;
Function
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
Gene Ontology
GO:0005938; GO:0005737; GO:0005925; GO:0098982; GO:0030426; GO:0030027; GO:0032991; GO:0001726; GO:0005085; GO:0019901; GO:0005089; GO:0043615; GO:0030032; GO:0043065; GO:0098974; GO:0099140; GO:0035023; GO:0007264
 
Gene Ontology