Protein Name
DNA polymerase zeta catalytic subunit
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
352776
Protein Length
3130
Protein Domain
3D Structure
(PDB ID : 3abd)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Function
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
Gene Ontology
GO:0005730; GO:0005654; GO:0016035; GO:0051539; GO:0003677; GO:0003887; GO:0046872; GO:0000166; GO:0006261; GO:0042276; GO:0090305