STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cytoplasm,Cytosol,Preautophagosomal structure;

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

GO:1990316; GO:0005776; GO:0030424; GO:0005737; GO:0030659; GO:0005829; GO:0097635; GO:0097629; GO:0097632; GO:0016020; GO:0043005; GO:0043025; GO:0000407; GO:0034045; GO:0005524; GO:0051020; GO:0051879; GO:0042802; GO:0004672; GO:0019901; GO:0004674; GO:0044877; GO:0017137; GO:0000045; GO:0006914; GO:0075044; GO:0048675; GO:0007409; GO:0034198; GO:0031669; GO:0021707; GO:0016236; GO:0000423; GO:0048671; GO:0031333; GO:0031175; GO:0031102; GO:0018105; GO:0018107; GO:2000786; GO:0046777; GO:0008104; GO:0021933; GO:0007265; GO:0031623; GO:0010506; GO:0010941; GO:0010468; GO:0051386; GO:0098780; GO:0042594