CaMKinet | Result

Gene

MITF

Synonyms

BHLHE32

Protein Name

Microphthalmia-associated transcription factor

UniProt ID

O75030-9 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000324246

NCBI Gene ID

4286

Molecular Weight

58795

Protein Length

526

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 4c7n)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Gene Ontology

GO:0005654; GO:0005634; GO:0032991; GO:0003682; GO:0001228; GO:0000981; GO:0001227; GO:0070888; GO:0046983; GO:0000978; GO:0046849; GO:0043010; GO:0044336; GO:0045165; GO:0030318; GO:0030336; GO:0000122; GO:0030316; GO:2000144; GO:0010628; GO:0045944; GO:0045893; GO:0065003; GO:0042127; GO:0045670; GO:2001141; GO:0006355; GO:0006351