PHF2 | Lysine-specific demethylase PHF2
 
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Sequence Viewer
Gene
PHF2
Synonyms
CENP-35 KIAA0662
Protein Name
Lysine-specific demethylase PHF2
UniProt ID
O75151 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000352185
NCBI Gene ID
5253
Molecular Weight
120775
Protein Length
1096
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 3kqi)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
1.14.11.-; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Nucleolus,Chromosome,Centromere,Kinetochore;
Function
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Gene Ontology
GO:0000777; GO:0000776; GO:0005730; GO:0005654; GO:0005634; GO:0051213; GO:0032452; GO:0032454; GO:0005506; GO:0035064; GO:0008270; GO:0001889; GO:0061188; GO:0006482
 
Gene Ontology