Protein Name
Serine/threonine-protein kinase ULK1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
112631
Protein Length
1050
Protein Domain
3D Structure
(PDB ID : 4wnp)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
Localization
Cytoplasm,Cytosol,Preautophagosomal structure;
Function
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Gene Ontology
GO:1990316; GO:0005776; GO:0030424; GO:0005737; GO:0005829; GO:0005789; GO:0097635; GO:0097629; GO:0097632; GO:0016020; GO:0005741; GO:0000407; GO:0034045; GO:0055037; GO:0005524; GO:0051020; GO:0042802; GO:0016301; GO:0004674; GO:0044877; GO:0017137; GO:0000045; GO:0006914; GO:0075044; GO:0048675; GO:0031669; GO:0016236; GO:0031333; GO:0031175; GO:0031102; GO:0018105; GO:0018107; GO:2000786; GO:0046777; GO:0008104; GO:0006468; GO:0010506; GO:0016241; GO:0042594; GO:0007165