CaMKinet | Result

Gene

E2F6

Synonyms

Protein Name

Transcription factor E2F6

UniProt ID

O75461 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000302159

NCBI Gene ID

1876

Molecular Weight

31844

Protein Length

281

Protein Domain

InterPro | Pfam

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

Gene Ontology

GO:0071339; GO:0005654; GO:0005634; GO:0090575; GO:0003677; GO:0003700; GO:0000981; GO:0046983; GO:0043565; GO:0003714; GO:0008134; GO:0070317; GO:0000122; GO:0045944; GO:0051726; GO:0000083