STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Nucleus speckle,Nucleus,PML body;

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

GO:0016607; GO:0005654; GO:0005634; GO:0016605; GO:0050681; GO:0003677; GO:0019899; GO:0008022; GO:0019904; GO:0061665; GO:0019789; GO:0003713; GO:0003714; GO:0031625; GO:0008270; GO:0030521; GO:0045444; GO:0000082; GO:0043066; GO:0000122; GO:0032436; GO:0033235; GO:0051152; GO:0045893; GO:0016925; GO:0065004; GO:0007259; GO:0042127; GO:0060334; GO:0007283; GO:0008542