Protein Name
Neuronal migration protein doublecortin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
40613
Protein Length
366
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cell projection;
Function
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration.
Gene Ontology
GO:0030424; GO:0005930; GO:0005737; GO:0005829; GO:0030425; GO:0030426; GO:0005874; GO:0043005; GO:0043025; GO:0008017; GO:0019901; GO:0048675; GO:0035082; GO:0007420; GO:0021952; GO:0048813; GO:0021766; GO:0035556; GO:0021819; GO:0001764; GO:0042461; GO:0048672; GO:0045807; GO:0021860; GO:0060041