PLEKHG5 | Pleckstrin homology domain-containing family G member 5
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
PLEKHG5
Synonyms
KIAA0720
Protein Name
Pleckstrin homology domain-containing family G member 5
UniProt ID
O94827-7 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000344570
NCBI Gene ID
57449
Molecular Weight
117451
Protein Length
1062
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cytoplasm,Cytoplasm,Perinuclear region,Cell membrane,Cell junction,Cell projection,Lamellipodium;
Function
Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.
Gene Ontology
GO:0005911; GO:0005737; GO:0005829; GO:0030139; GO:0030027; GO:0048471; GO:0005886; GO:0098793; GO:0005085; GO:0005089; GO:0035767; GO:0007186; GO:0043065; GO:0043123; GO:0099575; GO:0035023; GO:0051056