CaMKinet | Result

Gene

BCL10

Synonyms

CIPER CLAP

Protein Name

B-cell lymphoma/leukemia 10

UniProt ID

O95999 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000359612

NCBI Gene ID

8915

Molecular Weight

26252

Protein Length

233

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2mb9)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Perinuclear region,Membrane raft;

Function

Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

Gene Ontology

GO:0032449; GO:0005737; GO:0005881; GO:0005829; GO:0001772; GO:0005764; GO:0045121; GO:0005634; GO:0048471; GO:0032991; GO:0050700; GO:0019899; GO:0042802; GO:0019900; GO:0051059; GO:0002020; GO:0008022; GO:0043422; GO:0019901; GO:0043621; GO:0003713; GO:0008134; GO:0031625; GO:0002250; GO:0001783; GO:0008219; GO:0006968; GO:0071260; GO:0038095; GO:0007249; GO:0016064; GO:0045087; GO:0042226; GO:0031663; GO:0042109; GO:0002906; GO:0001843; GO:0043065; GO:0043280; GO:2001238; GO:0043123; GO:0045416; GO:0033674; GO:0032765; GO:0051092; GO:0042327; GO:0031398; GO:0050870; GO:0045893; GO:0051259; GO:0051291; GO:0051260; GO:0016567; GO:0050856; GO:0032094; GO:0009620; GO:0002237; GO:0002223; GO:0070231; GO:0050852; GO:0002224