STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Cell membrane,Endoplasmic reticulum membrane,Golgi apparatus membrane,Nucleus membrane,Endosome,Endosome membrane,Nucleus;Isoform 2: Secreted;

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity).Isoform 2 may act as an antagonist of EGF action.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

GO:0016324; GO:0009925; GO:0016323; GO:0009986; GO:0030665; GO:0005737; GO:0031901; GO:0030139; GO:0005789; GO:0005768; GO:0010008; GO:0005615; GO:0005925; GO:0000139; GO:0005887; GO:0016020; GO:0045121; GO:0097489; GO:0031965; GO:0005634; GO:0048471; GO:0005886; GO:0032991; GO:0043235; GO:0070435; GO:0045202; GO:0051015; GO:0005524; GO:0045296; GO:0005516; GO:0003682; GO:0003690; GO:0019899; GO:0048408; GO:0005006; GO:0042802; GO:0005178; GO:0004709; GO:0046934; GO:0046982; GO:0019901; GO:0019903; GO:0004713; GO:0005088; GO:0004714; GO:0004888; GO:0031625; GO:0001618; GO:0043006; GO:0007202; GO:0048143; GO:0030154; GO:0008283; GO:0007166; GO:0098609; GO:0071230; GO:0071276; GO:0071549; GO:0071364; GO:0071392; GO:0071260; GO:0034614; GO:0021795; GO:0007623; GO:0048546; GO:0016101; GO:0001892; GO:0007173; GO:0038128; GO:0061029; GO:0001942; GO:0042743; GO:0007611; GO:0097421; GO:0030324; GO:0010960; GO:0000165; GO:0061024; GO:0007494; GO:0060571; GO:0043066; GO:1905208; GO:0042059; GO:1901185; GO:0045930; GO:0045746; GO:0042177; GO:0048812; GO:0001503; GO:0042698; GO:0038083; GO:0018108; GO:0097755; GO:0045780; GO:0090263; GO:0030307; GO:0030335; GO:0008284; GO:0045737; GO:0045739; GO:0045740; GO:0050679; GO:0070374; GO:0048146; GO:1900087; GO:0050729; GO:0043406; GO:1901224; GO:0010750; GO:0033138; GO:0042327; GO:1903800; GO:1902722; GO:0051897; GO:1900020; GO:1903078; GO:0001934; GO:0048661; GO:0032930; GO:0051968; GO:0045944; GO:0045893; GO:0045907; GO:0046777; GO:0051205; GO:2000145; GO:0070372; GO:0046328; GO:0050999; GO:0050730; GO:0014066; GO:0006357; GO:0051592; GO:0033590; GO:0033594; GO:0006970; GO:0070141; GO:0007435; GO:0007165; GO:0043586; GO:0006412; GO:0007169; GO:0042060