MYC | Myc proto-oncogene protein
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
MYC
Synonyms
BHLHE39
Protein Name
Myc proto-oncogene protein
UniProt ID
P01106 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000367207
NCBI Gene ID
4609
Molecular Weight
48804
Protein Length
439
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1a93)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Nucleoplasm,Nucleus,Nucleolus;
Function
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).
Gene Ontology
GO:0000790; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0033613; GO:0003677; GO:0001228; GO:0003700; GO:0000981; GO:0001227; GO:0070888; GO:0046983; GO:0044877; GO:0070491; GO:0000978; GO:0008134; GO:1904837; GO:0001658; GO:0007050; GO:0006879; GO:0006974; GO:0035690; GO:0071456; GO:0034644; GO:0006338; GO:0051276; GO:0019221; GO:0006112; GO:0070371; GO:0044346; GO:0000082; GO:0000165; GO:0043066; GO:0051782; GO:0048147; GO:0045656; GO:0032873; GO:0000122; GO:0007219; GO:0015671; GO:0008284; GO:0043280; GO:2000573; GO:1905643; GO:0050679; GO:0048146; GO:0010628; GO:0002053; GO:0090096; GO:2001022; GO:0051973; GO:0045944; GO:0045893; GO:0016579; GO:0032986; GO:0010468; GO:0032204; GO:0006357; GO:0042493; GO:0010332; GO:0070848
 
Gene Ontology