Protein Name
Myelin basic protein
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
33117
Protein Length
304
Protein Domain
3D Structure
(PDB ID : 1bx2)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Myelin membrane;Isoform 3: Nucleus;
Function
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Gene Ontology
GO:0071944; GO:0009986; GO:0043218; GO:0033269; GO:0005622; GO:0043209; GO:0043025; GO:0005634; GO:0005886; GO:0032991; GO:0005516; GO:0002020; GO:0019911; GO:0008366; GO:0007417; GO:0007268; GO:0006955; GO:0035633; GO:0000165; GO:0061024; GO:0042552; GO:0034115; GO:1904209; GO:2000778; GO:1904685; GO:0009636; GO:0007605; GO:0021762