Gene
Synonyms
HER2 MLN19 NEU NGL
Protein Name
Receptor tyrosine-protein kinase erbB-2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
137910
Protein Length
1255
Protein Domain
3D Structure
(PDB ID : 5my6)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Localization
Isoform 1: Cell membrane,Cytoplasm,Perinuclear region,Nucleus;Isoform 2: Cytoplasm,Nucleus;Isoform 3: Cytoplasm,Nucleus;
Function
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Gene Ontology
GO:0016324; GO:0009925; GO:0016323; GO:0005829; GO:0010008; GO:0016021; GO:0005887; GO:0043209; GO:0005634; GO:0048471; GO:0005886; GO:0043235; GO:0005524; GO:0043125; GO:0042802; GO:0046934; GO:0008022; GO:0046983; GO:0046982; GO:0019903; GO:0004713; GO:0005088; GO:0001042; GO:0004714; GO:0004888; GO:0008283; GO:0007166; GO:0071364; GO:0071363; GO:0007167; GO:0038128; GO:0007507; GO:0035556; GO:0000165; GO:0008045; GO:0042552; GO:1901185; GO:0033088; GO:0007528; GO:0030182; GO:0048709; GO:0007422; GO:0014065; GO:0045785; GO:0030307; GO:0008284; GO:0050679; GO:0043547; GO:0043406; GO:0043410; GO:0051897; GO:0001934; GO:0090314; GO:0045943; GO:0045727; GO:0046777; GO:0006468; GO:0045765; GO:2000145; GO:0070372; GO:0032886; GO:0006357; GO:0007165; GO:0007169; GO:0042060