CaMKinet | Result

Gene

HSPB1

Synonyms

HSP27 HSP28

Protein Name

Heat shock protein beta-1

UniProt ID

P04792 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000248553

NCBI Gene ID

3315

Molecular Weight

22783

Protein Length

205

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2n3j)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Nucleus,Cytoplasm,Cytoskeleton,Spindle;

Function

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742).

Gene Ontology

GO:1904115; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005615; GO:0005925; GO:0005634; GO:0005886; GO:0000502; GO:0005819; GO:0030018; GO:0042802; GO:0044183; GO:0042803; GO:0019901; GO:0005080; GO:0008426; GO:0003723; GO:0043130; GO:0099641; GO:0035924; GO:0061077; GO:0035556; GO:0043066; GO:1902176; GO:0006469; GO:0070527; GO:0045766; GO:0043536; GO:2001028; GO:0038033; GO:0032731; GO:0042535; GO:0010506; GO:0043122; GO:0043488; GO:0001932; GO:0006446; GO:0006986; GO:0009615; GO:0001895