Protein Name
Eukaryotic translation initiation factor 2 subunit 1
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
36112
Protein Length
315
Protein Domain
3D Structure
(PDB ID : 1kl9)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Stress granule;
Function
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Gene Ontology
GO:0010494; GO:0005829; GO:0033290; GO:0005850; GO:0005851; GO:0070062; GO:0097451; GO:0016020; GO:0043614; GO:0005634; GO:0005844; GO:0045202; GO:0044207; GO:0043022; GO:0003723; GO:0003743; GO:0007568; GO:0034198; GO:0034605; GO:0034599; GO:0034644; GO:1905098; GO:0032057; GO:0036499; GO:1901216; GO:2000676; GO:0046777; GO:0034976; GO:1990737; GO:0034063; GO:0006413; GO:0055085