STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cell membrane,Cell projection,Invadopodium membrane,Cell projection,Ruffle membrane,Recycling endosome,Melanosome,Cleavage furrow,Cell projection,Lamellipodium,Cell projection,Ruffle,Cell junction,Focal adhesion,Cell surface;Isoform 5: Cell membrane,Sarcolemma,Cell junction;

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.(Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.(Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.(Microbial infection) Acts as a receptor for Mammalian reovirus.(Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

GO:0009986; GO:0032154; GO:0005737; GO:0043197; GO:0009897; GO:0070062; GO:0030175; GO:0005925; GO:0097386; GO:0098978; GO:0099699; GO:0034665; GO:0034680; GO:0034681; GO:0034666; GO:0034667; GO:0034677; GO:0034678; GO:0008305; GO:0014704; GO:0071438; GO:0030027; GO:0042470; GO:0016020; GO:0045121; GO:0035748; GO:0031594; GO:0048471; GO:0005886; GO:0043235; GO:0055037; GO:0001726; GO:0032587; GO:0042383; GO:0098685; GO:0003779; GO:0045296; GO:0050839; GO:0098639; GO:0015026; GO:0001968; GO:0005178; GO:0043236; GO:0046872; GO:0002020; GO:0046982; GO:0044877; GO:0001618; GO:0048675; GO:0030183; GO:0071711; GO:0007161; GO:0055007; GO:0033627; GO:0001708; GO:0016477; GO:0002042; GO:0030030; GO:0033631; GO:0007160; GO:0031589; GO:0006968; GO:0071404; GO:0019221; GO:0048813; GO:0030198; GO:0021943; GO:0000082; GO:0008354; GO:0034113; GO:0007156; GO:0001701; GO:0007229; GO:0030032; GO:0007159; GO:0050900; GO:0050901; GO:0048333; GO:0050804; GO:2000811; GO:0045596; GO:0035024; GO:0006909; GO:0045766; GO:0043065; GO:0008284; GO:0043547; GO:0051897; GO:1903078; GO:2000273; GO:0031623; GO:0051726; GO:0010710; GO:0050776; GO:0045214; GO:0008542