CACNA1S | Voltage-dependent L-type calcium channel subunit alpha-1S
 
image/svg+xmlExtracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion None Substrate Localization legend

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Sequence Viewer
Gene
CACNA1S
Synonyms
CACH1 CACNL1A3
Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt ID
P07293 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
100009585
Molecular Weight
212029
Protein Length
1873
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1du1)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Cell membrane,Sarcolemma,T-tubule;
Function
Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115 PubMed:15201141, PubMed:27621462). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Gene Ontology
GO:0005887; GO:1990454; GO:0030315; GO:0005516; GO:0044325; GO:0046872; GO:0005245; GO:0070588; GO:0071313; GO:0060314
 
Gene Ontology