CaMKinet | Result

Gene

MYLK2

Synonyms

Protein Name

Myosin light chain kinase 2, skeletal/cardiac muscle

UniProt ID

P07313 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

NCBI Gene ID

100009051

Molecular Weight

65468

Protein Length

608

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2bbm)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.18; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

[myosin light chain]-L-serine + ATP = [myosin light chain]-O-phospho-L-serine + ADP + H(+)[myosin light chain]-L-threonine + ATP = [myosin light chain]-O-phospho-L-threonine + ADP + H(+)

Localization

Cytoplasm;

Function

Implicated in the level of global muscle contraction and cardiac function (By similarity). Phosphorylates a specific serine in the N-terminus of a myosin light chain.

Gene Ontology

GO:0005737; GO:0005524; GO:0005516; GO:0004683; GO:0004687; GO:0032971