CaMKinet | Result

Gene

QDPR

Synonyms

DHPR SDR33C1

Protein Name

Dihydropteridine reductase

UniProt ID

P09417 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000281243

NCBI Gene ID

5860

Molecular Weight

25790

Protein Length

244

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1hdr)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

1.5.1.34; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH

Localization

Function

The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.

Gene Ontology

GO:0005737; GO:0005829; GO:0070062; GO:0043005; GO:0004155; GO:0009055; GO:0070404; GO:0070402; GO:0042803; GO:0006520; GO:0035690; GO:0051066; GO:0006559; GO:0001889; GO:0010044; GO:0033762; GO:0010288; GO:0006729