CaMKinet | Result

Gene

TPM1

Synonyms

C15orf13 TMSA

Protein Name

Tropomyosin alpha-1 chain

UniProt ID

P09493 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000267996

NCBI Gene ID

7168

Molecular Weight

32709

Protein Length

284

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3mud)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Cytoskeleton;

Function

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Gene Ontology

GO:0015629; GO:0005884; GO:0032059; GO:0005856; GO:0005829; GO:0005862; GO:0032587; GO:0030017; GO:0001725; GO:0003779; GO:0051015; GO:0008092; GO:0042802; GO:0046982; GO:0042803; GO:0005200; GO:0008307; GO:0007015; GO:0060048; GO:0034614; GO:0007010; GO:0001701; GO:0006936; GO:0030049; GO:0030336; GO:1904753; GO:1904706; GO:0032781; GO:0045785; GO:0003065; GO:0051496; GO:0008360; GO:0008016; GO:0006937; GO:0031529; GO:0045214; GO:0055010; GO:0042060