CaMKinet | Result

Gene

ALOX5

Synonyms

LOG5

Protein Name

Arachidonate 5-lipoxygenase

UniProt ID

P09917 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000363512

NCBI Gene ID

240

Molecular Weight

77983

Protein Length

674

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2abv)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

1.13.11.34; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4

Localization

Cytoplasm,Nucleus matrix,Nucleus membrane;

Function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Gene Ontology

GO:0005829; GO:0005576; GO:0005615; GO:1904813; GO:0005635; GO:0005641; GO:0016363; GO:0031965; GO:0005654; GO:0034774; GO:0004051; GO:0005506; GO:0019221; GO:0035655; GO:0019370; GO:0006691; GO:0002540; GO:0019372; GO:0042759; GO:0043312