Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
18789
Protein Length
166
Protein Domain
3D Structure
(PDB ID : 5tby)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Myofibril,Sarcomere,A band;
Function
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
Gene Ontology
GO:0031672; GO:0097512; GO:0005856; GO:0005829; GO:0030016; GO:0016459; GO:0030017; GO:0003785; GO:0005509; GO:0032036; GO:0008307; GO:0060048; GO:0055003; GO:0060047; GO:0007507; GO:0042694; GO:0048747; GO:0030049; GO:0030308; GO:0098735; GO:0009791; GO:0006942; GO:0002026; GO:0055010