CaMKinet | Result

Gene

Mylk

Synonyms

Protein Name

Myosin light chain kinase, smooth muscle

UniProt ID

P11799 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

NCBI Gene ID

Molecular Weight

210446

Protein Length

1906

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1cdl)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.18; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

[myosin light chain]-L-serine + ATP = [myosin light chain]-O-phospho-L-serine + ADP + H(+)[myosin light chain]-L-threonine + ATP = [myosin light chain]-O-phospho-L-threonine + ADP + H(+)

Localization

Cytoplasm,Cytosol,Membrane;

Function

Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals.

Gene Ontology

GO:0005829; GO:0031430; GO:0016020; GO:0030017; GO:0005865; GO:0030018; GO:0051015; GO:0005524; GO:0005516; GO:0046872; GO:0051371; GO:0004687; GO:0008307; GO:0048739; GO:0055008; GO:0055003; GO:0006936; GO:0045214; GO:0030241; GO:0030240; GO:0071688