Nr4a1 | Nuclear receptor subfamily 4 group A member 1
 
Sequence Viewer
Gene
Nr4a1
Synonyms
Gfrp Hmr N10 Nur77
Protein Name
Nuclear receptor subfamily 4 group A member 1
UniProt ID
P12813 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSMUSP00000023779
NCBI Gene ID
15370
Molecular Weight
64738
Protein Length
601
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus,Cytoplasm;
Function
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (PubMed:22427340).
Gene Ontology
GO:0005829; GO:0031965; GO:0005634; GO:0005667; GO:0003677; GO:0001228; GO:0035259; GO:0004879; GO:0046982; GO:0042803; GO:0000978; GO:0000977; GO:0043565; GO:0003707; GO:0008134; GO:0008270; GO:0006915; GO:0002042; GO:0071376; GO:0044344; GO:0071310; GO:0035924; GO:0035767; GO:0045444; GO:0045786; GO:0043154; GO:0043065; GO:0001938; GO:0045944; GO:0045893; GO:0061469; GO:0010035; GO:0035914
 
Gene Ontology