STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Nucleus,Chromosome;

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

GO:0005829; GO:0005576; GO:1904813; GO:0043564; GO:0016020; GO:0070419; GO:0000784; GO:0000783; GO:0005730; GO:0005654; GO:0005634; GO:0032991; GO:0032993; GO:0034774; GO:0005667; GO:0051575; GO:0005524; GO:0004003; GO:0030332; GO:0003684; GO:0003677; GO:0003690; GO:0008022; GO:0044877; GO:0003723; GO:0042162; GO:0044212; GO:0002218; GO:0007420; GO:0071475; GO:0071480; GO:0071481; GO:0006266; GO:0006310; GO:0097680; GO:0006303; GO:0075713; GO:0045087; GO:0045892; GO:0043312; GO:0045860; GO:0045944; GO:0045893; GO:0032481; GO:0051290; GO:0048660; GO:0000723