CaMKinet | Result

Gene

LCP1

Synonyms

PLS2

Protein Name

Plastin-2

UniProt ID

P13796 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000315757

NCBI Gene ID

3936

Molecular Weight

70288

Protein Length

627

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2d85)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cytoplasm,Cytoskeleton,Cell junction,Cell projection,Cell projection,Ruffle membrane;

Function

Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).

Gene Ontology

GO:0015629; GO:0005884; GO:0032432; GO:0030054; GO:0005737; GO:0005829; GO:0070062; GO:0005615; GO:0030175; GO:0005925; GO:0001891; GO:0005886; GO:0002102; GO:0001726; GO:0032587; GO:0003779; GO:0051015; GO:0005509; GO:0051020; GO:0042802; GO:0005178; GO:0051017; GO:0051639; GO:0031100; GO:0016477; GO:0022617; GO:0035722; GO:0071803; GO:0010737; GO:0033157; GO:0002286