Gene
Synonyms
OIP3 PK2 PK3 PKM2
Protein Name
Pyruvate kinase PKM
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
57937
Protein Length
531
Protein Domain
3D Structure
(PDB ID : 1t5a)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate
Localization
Cytoplasm,Nucleus;
Function
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:17308100, PubMed:18191611, PubMed:21620138). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity).
Gene Ontology
GO:0005929; GO:0062023; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:1903561; GO:1904813; GO:0005739; GO:0005634; GO:1902912; GO:0034774; GO:0031982; GO:0043531; GO:0005524; GO:0045296; GO:0042802; GO:0016301; GO:0000287; GO:0023026; GO:0030955; GO:0004743; GO:0003723; GO:0070324; GO:0031100; GO:0061621; GO:0032869; GO:0006096; GO:0001889; GO:0043312; GO:1903672; GO:0012501; GO:0051289; GO:0009629; GO:0001666; GO:0014870; GO:0007584; GO:0043403