STRING | IntAct | MINT

Open Targets | OMIM

Catalytic Site Atlas

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Cell membrane,Cell projection,Axon,Cytoplasmic vesicle,Membrane,Caveola,Cell projection,Dendrite;

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

GO:0030424; GO:0005901; GO:0070852; GO:0005737; GO:0031410; GO:0005829; GO:0030425; GO:0043198; GO:0098978; GO:0005887; GO:0099055; GO:0099056; GO:0016020; GO:0043025; GO:0005886; GO:0071886; GO:0004930; GO:0004993; GO:0001965; GO:0030594; GO:0044877; GO:0051378; GO:0007202; GO:0007568; GO:0014824; GO:0048148; GO:0008219; GO:0007268; GO:0050966; GO:0050965; GO:0007186; GO:0007187; GO:0007613; GO:0043267; GO:0051967; GO:0014065; GO:0007200; GO:0007208; GO:0008284; GO:0007204; GO:0070374; GO:0045600; GO:0045821; GO:0043406; GO:0050731; GO:0010513; GO:0045907; GO:0044380; GO:0014059; GO:2000300; GO:0051209; GO:0042493; GO:0019233; GO:0030431; GO:0001659; GO:0014832