POU2F1 | POU domain, class 2, transcription factor 1
 
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Sequence Viewer
Gene
POU2F1
Synonyms
OCT1 OTF1
Protein Name
POU domain, class 2, transcription factor 1
UniProt ID
P14859 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
ENSP00000356836
NCBI Gene ID
5451
Molecular Weight
76472
Protein Length
743
Protein Domain
InterPro | Pfam
3D Structure
(PDB ID : 1cqt)
PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
-
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
-
Localization
Nucleus;
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Gene Ontology
GO:0005783; GO:0043231; GO:0005654; GO:0005634; GO:0090575; GO:0003677; GO:0000981; GO:0000979; GO:0000978; GO:0043565; GO:0019221; GO:0045892; GO:0045944; GO:0042795
 
Gene Ontology