CaMKinet | Result

Gene

HNRNPL

Synonyms

HNRPL

Protein Name

Heterogeneous nuclear ribonucleoprotein L

UniProt ID

P14866 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000221419

NCBI Gene ID

3191

Molecular Weight

64133

Protein Length

589

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 3r27)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus,Nucleoplasm,Cytoplasm;

Function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).

Gene Ontology

GO:0005829; GO:0070062; GO:0016020; GO:0005654; GO:0005634; GO:0048471; GO:0045120; GO:1990904; GO:0035770; GO:0003730; GO:1990715; GO:0097157; GO:0003723; GO:0044212; GO:0034198; GO:0007623; GO:0000398; GO:0048025; GO:1902416; GO:0045727; GO:0000381; GO:1901652; GO:0016070; GO:0006396