CaMKinet | Result

Gene

BRAF

Synonyms

BRAF1 RAFB1

Protein Name

Serine/threonine-protein kinase B-raf

UniProt ID

P15056 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000493543

NCBI Gene ID

673

Molecular Weight

84437

Protein Length

766

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 5jsm)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1; (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Localization

Nucleus,Cytoplasm,Cell membrane;

Function

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.

Gene Ontology

GO:0044297; GO:0005829; GO:0043231; GO:0005739; GO:0043005; GO:0005634; GO:0005886; GO:0005524; GO:0005509; GO:0042802; GO:0004709; GO:0031434; GO:0046982; GO:0004672; GO:0004674; GO:0009887; GO:0043369; GO:0043367; GO:0071277; GO:0035690; GO:1990090; GO:0090150; GO:0060324; GO:0060323; GO:0060291; GO:0000165; GO:0002318; GO:0043066; GO:2000352; GO:0010764; GO:0043524; GO:2000301; GO:0048680; GO:0050772; GO:0070374; GO:0010628; GO:0010828; GO:0033138; GO:0051496; GO:1900026; GO:0051291; GO:0006468; GO:0042127; GO:0045580; GO:0051591; GO:0043434; GO:0035019; GO:0050852; GO:0048538; GO:0030878; GO:0070413; GO:0008542