Lipe | Hormone-sensitive lipase
 
Sequence Viewer
Gene
Lipe
Synonyms
-
Protein Name
Hormone-sensitive lipase
UniProt ID
P15304 [go to UniProt ] [go to PDBe-KB ]
Ensembl Gene ID
-
NCBI Gene ID
25330
Molecular Weight
116812
Protein Length
1068
Protein Domain
InterPro | Pfam
Target by Small Molecules
chEMBL
Protein-protein Interaction Database
STRING | IntAct | MINT
Gene Expression
Gene Expression Atlas | The Human Protein Atlas
Drugs and Diseases
Open Targets | OMIM
Enzyme Class
3.1.1.79; (BRENDA)
Catalytic Site
Catalytic Site Atlas
Catalytic Activity
a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)
Localization
Cell membrane,Membrane,Caveola,Cytoplasm,Cytosol;
Function
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Gene Ontology
GO:0005901; GO:0005737; GO:0005829; GO:0005615; GO:0005811; GO:0005739; GO:0005634; GO:0047372; GO:0033878; GO:0016788; GO:0042134; GO:0008203; GO:0007565; GO:0016042; GO:0042493; GO:0006363; GO:0006361; GO:0019433
 
Gene Ontology