Gene
Synonyms
CACH2 CACN2 CACNL1A1 CCHL1A1
Protein Name
Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
242784
Protein Length
2171
Protein Domain
3D Structure
(PDB ID : 4dey)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cell membrane,Cell membrane,Sarcolemma,Perikaryon,Cell junction,Synapse,Postsynaptic cell membrane,Postsynaptic density,Cell projection,Dendrite,Cell membrane,Sarcolemma,T-tubule;
Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:2474130, PubMed:2169433, PubMed:8232554, PubMed:9502794, PubMed:9278523, PubMed:15615847, PubMed:17525370, PubMed:21127204, PubMed:22928916, PubMed:23145875, PubMed:29363593, PubMed:22649239). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (PubMed:23145875). Plays an important role in excitation-contraction coupling in the heart (PubMed:17525370, PubMed:22928916, PubMed:23145875). Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (By similarity). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Gene Ontology
GO:0030054; GO:0030425; GO:0016021; GO:0005887; GO:1990454; GO:0043204; GO:0005886; GO:0014069; GO:0045211; GO:0042383; GO:0030315; GO:0005891; GO:0005516; GO:0008331; GO:0046872; GO:0005245; GO:0070588; GO:0061577; GO:0060402; GO:0061337; GO:0045762; GO:0007204; GO:0010881; GO:0098903