CaMKinet | Result

Gene

TCF3

Synonyms

BHLHB21 E2A ITF1

Protein Name

Transcription factor E2-alpha

UniProt ID

P15923 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000262965

NCBI Gene ID

6929

Molecular Weight

67600

Protein Length

654

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1hlh)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Gene Ontology

GO:0005737; GO:0000790; GO:0016607; GO:0005654; GO:0005634; GO:0032991; GO:0090575; GO:0005667; GO:0043425; GO:0003677; GO:0003700; GO:0000981; GO:0001227; GO:0070888; GO:0035326; GO:0031435; GO:0046982; GO:0042803; GO:0070491; GO:0000978; GO:0003713; GO:0008134; GO:0070644; GO:0030183; GO:0002326; GO:0033152; GO:0000122; GO:0030890; GO:0045787; GO:0051091; GO:0051149; GO:0045666; GO:0045944; GO:0045893; GO:2000045; GO:1902036; GO:0006355; GO:0006351