CaMKinet | Result

Gene

ITGB4

Synonyms

Protein Name

Integrin beta-4

UniProt ID

P16144 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000200181

NCBI Gene ID

3691

Molecular Weight

202167

Protein Length

1822

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1qg3)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Cell membrane,Cell membrane,Cell junction,Hemidesmosome;

Function

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).

Gene Ontology

GO:0030054; GO:0031252; GO:0009986; GO:0070062; GO:0005925; GO:0030056; GO:0008305; GO:0005886; GO:0043235; GO:0001664; GO:0005178; GO:0097186; GO:0006914; GO:0007155; GO:0033627; GO:0016477; GO:0048870; GO:0007160; GO:0048565; GO:0030198; GO:0031581; GO:0007229; GO:0048333; GO:0035878; GO:0072001; GO:0009611; GO:0043588