CaMKinet | Result

Gene

CREB1

Synonyms

Protein Name

Cyclic AMP-responsive element-binding protein 1

UniProt ID

P16220 [go to UniProt ] [go to PDBe-KB ]

Ensembl Gene ID

ENSP00000236995

NCBI Gene ID

1385

Molecular Weight

36688

Protein Length

341

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 2lxt)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

Localization

Nucleus;

Function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene Ontology

GO:1990589; GO:0030424; GO:0005759; GO:0005719; GO:0005654; GO:0005634; GO:0005667; GO:1990763; GO:0035497; GO:0001228; GO:0003700; GO:0000981; GO:0019899; GO:0035035; GO:0030544; GO:0042802; GO:0001102; GO:0000980; GO:0000978; GO:0001225; GO:0003712; GO:0007568; GO:0007409; GO:0071398; GO:0035729; GO:1990314; GO:1990830; GO:1990090; GO:0036120; GO:0071300; GO:0071294; GO:0034670; GO:0007623; GO:0007595; GO:0060430; GO:0007613; GO:1901215; GO:0010944; GO:0021983; GO:0043065; GO:0055025; GO:0045600; GO:0046887; GO:0046889; GO:1900273; GO:0040018; GO:0045672; GO:0045899; GO:0045944; GO:0045893; GO:0032916; GO:0006468; GO:0050821; GO:0008361; GO:0042752; GO:0048145; GO:0060251; GO:0014823; GO:0033762; GO:0001666; GO:1902065; GO:0035094; GO:0010033; GO:0033363; GO:0007165; GO:0006366; GO:0007179; GO:0060509; GO:0016032; GO:0008542