Protein Name
Oxysterol-binding protein 1
UniProt ID
Ensembl Gene ID
-
NCBI Gene ID
Molecular Weight
89478
Protein Length
809
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
-
Catalytic Site
Localization
Cytoplasm,Cytosol,Cytoplasm,Perinuclear region,Golgi apparatus membrane,Endoplasmic reticulum membrane;
Function
Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:18165705). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (By similarity). Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity).
Gene Ontology
GO:0005829; GO:0005789; GO:0000139; GO:0048471; GO:0005802; GO:0015485; GO:0070273; GO:0015248; GO:0032367; GO:0015918